Recently Funded Projects

Portable Optical Sensor for Rapid, Non-Invasive, and On-Site Diagnosis of Tuberculosis

Principal Investigator's Organization (PIO):
Principal Investigator (PI):
Imran Cheema
Partner Organization(s)
National TB Control Program
Project Details:
Duration 34 months
Budget PKR 31.8 Million
Executive Summary

Brainchild of Dr. Muhammad Imran Cheema, a portable optical sensor is being developed for on-site diagnosis of tuberculosis (TB); a disease which is known to every second household in Pakistan.

Using laser Raman spectroscopy, a simple breath test will analyze a patient for rapid, on-site diagnosis. The inner walls of the collection chamber they breathe into are chemically treated to capture the organic TB biomarkers present in the patient's breath. A laser beam is then passed through the chamber, and the transmitted light is detected as a function of the raman shifts, determining the frequency.

The diagnosis of TB is then performed based on the chemically-specific spectroscopic signatures of the TB biomarkers present in the breath. This process will provide a novel TB sensor which is non-invasive, accurate, sensitive, and label free. By developing an easy to use non-invasive optical sensor, immediate TB diagnosis can be provided without the aid of specialized laboratory personnel. This is also easily portable to remote areas with lack of healthcare infrastructure.


Original text